11
nov

Project 10: Evaluation of safety and efficacy of a Thermal Pulsation System versus other treatments of meibomian gland dysfunction

Project Description Meibomian gland dysfunction (MGD) is the leading cause of evaporative dry eye. Despite the various treatment options for MGD, it is often difficult to obtain total relief of signs and symptoms and this condition can lead to sub-optimal clinical outcomes and reduced patient satisfaction after laser vision correction. The purpose of this study is to determine the safety
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10
nov

Project 9: Development of an in-vitro animal model to evaluate novel pharmaceutical approached to DED management

Project Description Barabino and Dana (2004) concluded "The existing animal models of dry eye mimic different pathogenic mechanisms of dry eye, but at the moment none of them seems to mirror precisely the complexity and chronicity of this frequent and debilitating condition." The main disadvantage of most in-vitro models is that the experimental time frame is limited to only a
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9
nov

Project 8: Bio-adhesive polymers containing liposomes for DED treatment

Project Description Artificial tears are prescribed alone or in combination with other therapies to treat DED. Although no pharmaceutical formulas on the market aim to replace the preocular tear film, lipid substitute formulations are presently in the early clinical trial stage. The UCM group has developed an artificial tear containing hydrophilic and lipid components that resemble the preocular tear film.
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8
nov

Project 7: DED and cataract surgery

Project Description A dysfunctional pre-corneal tear film may limit the accuracy of pre-surgical calculations and impact post-operative vision, refractive and patient-reported outcomes after cataract surgery. A decrease in tear secretion or an increase in tear evaporation can result in hyperosmolarity of the tear film. The purpose of this study is to determine the variability of pre-surgical calculations in normal and
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7
nov

Project 6: Environmental Risk Factor for DED

Project Description While individual reports have been published of environmental factors such as temperature, humidity and air pollution causing dry eye symptoms, no large-scale systematic studies of their effects in humans have been conducted. These factors can be simulated in a controlled environmental chamber. Since the prevalence of dry eyes is reportedly far higher among contact lens wearers, a contact
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6
nov

Project 5: Predicting contact lens related dry eye

Project Description The latest Tear Film and Ocular Surface report (2013) emphasises the importance of contact lens interaction with tear film. Many studies conclude that all soft contact lens materials adversely affect tear film physiology. Differences have recently been shown to exist in in-vivo tear film surface quality, depending on lens type. The aim of the study is to use
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5
nov

Project 4: Evaluation of changes in tear film metrics and ocular signs induced by different types of refractive correction

Project Description The aim of this project is to evaluate changes in tear film metrics and ocular signs induced by different types of refractive correction (corneal refractive surgery, intraocular lens implantation and contact lenses) focusing on the older population, since the prevalence of DED increases with age and due to presbyopia most people over 45 need refractive correction for distance,
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4
nov

Project 3: Non-invasive measurement of tear film surface quality

Project Description It is essential to use non-invasive methods for assessing tear film in routine clinical practice. Lateral shearing interferometry has proven to be the best method for the non-invasive characterisation of tear film surface quality. It can differentiate normal from dry eyes and has the unique ability to distinguish contact lens material on eyes. Nevertheless, two major drawbacks limit
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3
nov

Project 2: Infrared Imaging of Meibomian Gland Structure

Project Description Meibomian gland dysfunction (MGD) causes evaporative dry eye. The International Workshop on MGD formally defined it as a chronic, diffuse abnormality of the meibomian glands, commonly characterized by terminal duct obstruction and/or qualitative/quantitative changes in glandular secretion. It may result in alteration of the tear film, eye irritation symptoms, clinically apparent inflammation and ocular surface disease. With the
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2
nov

Project 1: Biomarkers trends for early diagnosis of DED

Project Description The aim of this project is to analyse the propensity to develop DED in the near future and anticipate its evolution. Using mathematical models and descriptors, it will explore the intra-day and visit-to-visit trends of certain specific biomarkers in a healthy population and in a population with incipient symptomatology. Host InstitutionUniversity of Valencia (Spain)